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Notably, six of those metabolites were subsequently also detected in blood cell samples of human volunteers after ingestion of multiple doses of 200 and 300 mg Pycnogenol (28)

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Paroni R, De Vecchi E, Cighetti G, Arcelloni C, Fermo I, Grossi A et al

The authors found that BPDB-based MOFs exhibited GSH concentration-dependent NO release (Figure 2G), and four molecules of NO can be released from each BPDB molecule provoked by two molecules of GSH (Figure 2H)

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