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Interestingly, GIPR agonism blocks PYY (155) and GLP-1 receptor mediated emesis and illness behaviors in preclinical species (156)

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The control group was significantly different than the current time point for both medications (Semaglutide: B = 10.29, SE = 3.02, p = 0.004, Tirzepatide: B = 11.445, SE = 3.08, p = 0.003), but was not different when compared to prior to starting each medication (n.s.)