In late-stage trials aficamten improved exercise capacity and reduced symptoms in patients with the condition
How dysbiosis impairs GLP-1 signaling Gut dysbiosis, characterized by low bacterial diversity, overgrowth of inflammatory species, and reduced populations of beneficial bacteria, creates a cascade of metabolic problems
Ferguson SD, Bindal S, Bassett RL, Haydu LE, McCutcheon IE, Heimberger AB, Li J, O'Brien BJ, Guha-Thakurta N, Tetzlaff MT, Tawbi H, Davies MA , Glitza IC
(2020) demonstrated that activation of the unfolded protein response, specifically through phosphorylation of PERK (protein kinase R-like ER kinase), induces a unique reactive state in astrocytes
M.WangB.XuS
If you are on a GLP-1 medication, work with your doctor to monitor your bloodwork, specifically vitamin D, iron (ferritin), B vitamins, and calcium levels