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Oxidative Imbalance and Reduced GR Function Several specific scenarios create conditions where hydrogen water's mechanism may provide advantages over relying solely on GR-mediated glutathione recycling: NADPH deficiency states : Conditions that compromise NADPH production, such as glucose-6-phosphate dehydrogenase deficiency, metformin therapy, or severe caloric restriction, limit GR function due to insufficient cofactor availability

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doi: 10.1016/j.bcp.2010.04.032 153 SpencerKRMehnertJM

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Fig S2) than mice in all other groups