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In the liver, feeding-induced FXR activation elevates SHP expression, which forms a complex with CREB to recruit lysine-specific demethylase 1 (LSD1) to the promoters of ATGs such as Tfeb, Ulk1 , and Atg7

Apart from development, glutathione is crucial for stress response by (i) neutralizing radicals, (ii) participating in heavy metal tolerance, either directly or as a constitutive element of phytochelatins, (iii) contributing to the regeneration of antioxidant molecules such as ascorbate and -tocopherol, and (iv) providing electrons and protons to glutathione transferases (GSTs) or to peroxiredoxins, both with and without the involvement of glutaredoxins (Grxs) for peroxide removal (Rouhier et al., 2008)

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Andrology 8 , 18841894