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For superoxide anion, the main ROS, a first line of defense is represented by the enzyme superoxide dismutase, localized in the mitochondrial matrix

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This property makes NAC particularly beneficial for individuals with chronic obstructive pulmonary disease (COPD) and cystic fibrosis

It is composed of three amino acids: glycine, glutamine and cysteine

There is little data about the concentrations of GSH in the nucleus and endoplasmic reticulum largely because of a lack of adequate techniques to accurately determine the GSH pool at those locations (15, 69, 72, 73)

Dosage recommendations reflect clinical practice patterns and preclinical dose extrapolation, not FDA-approved labeling