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Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research

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Another group that may benefit includes adults experiencing the natural age-related decline in growth hormone secretion, often referred to as somatopause

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Therefore, further studies of the functions and mechanisms of various target molecules are necessary, and their effectiveness and safety through must be evaluated through animal experiments and clinical trials