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[11] Tirzepatide Once Weekly for the Treatment of Obesity | New England Journal of Medicine. Accessed: Nov

The mechanism of heart rate increase with semaglutide is primarily indirect, mediated through autonomic nervous system effects rather than direct cardiac stimulation

These preclinical findings further implicate glucagon activation as the distinguishing factor between incretin receptor mono-, dual-, and triagonists, and they point to unimolecular polypharmacology as an efficient way to target several mechanisms causing obesity

USA 102 , 761766 (2005)

Another source of superoxide is the energy production in the cells