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The difference isnt dramatic, but rates of nausea and diarrhea are modestly higher with tirzepatide compared to semaglutide in clinical trials

Consider combination approaches Some researchers explore stacking additional compounds with their primary GLP-1 agonist

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To investigate the metabolic effects more comprehensively, we used the Oxymax system to measure energy expenditure and metabolic changes and the Echo-MRI system as well as X-ray CT to assess muscle mass changes