Most microdose patients notice improvements in appetite regulation and energy within the first 23 weeks without the nausea or food aversion that can accompany standard dosing
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Experimental models include isolated perfused hearts (Langendorff), ex vivo working heart preparations, in vivo echocardiography with metabolic phenotyping, transgenic models affecting carnitine metabolism (OCTN2 knockout, CPT-I variants), and large animal models of myocardial infarction
