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The amine and carboxylic acid groups of carnitine are the key groups for OCTN2 to recognize it, and the hydroxyl group of carnitine is esterified by acyl derivatives and does not hinder the recognition effect of OCTN2, indicating that OCTN2 has high substrate diversity and adaptability and is able to process a variety of acylcarnitines [162]

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Beyond modest lipid improvements, GLP-1 receptor agonists have demonstrated substantial cardiovascular benefits in large-scale outcome trials, establishing them as important cardioprotective agents for appropriate patients