516 It has been observed that ZNF282 (Zinc finger protein 282) functions as an E2F1 co-activator in esophageal squamous-cell carcinoma (ESCC), inducing accelerated transcription of E2F1 target genes like CCND2 , CCNA1 , CDC2 , and CDC6 , facilitating G1/S transition and cell cycle progression
Sakaguchi S & Sakaguchi N (1990) Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease
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