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Ethics statement The animal study was approved by The Ethics Committee approved all procedures for Animal Research of King Saud University, Riyadh (IRB No: KSU-SE-23-58)

Pastore, P., Roverso, M., Tedesco, E., Micheletto, M., Mantovan, E., Zanella, M., et al

SIRT1 and SIRT6 deacetylate specific histone residues, including H3K9, H3K14, and H1K26, promoting chromatin condensation and transcriptional silencing of specific gene programs

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Since GSH patrols have the cellular environment and put out oxidative free radical flames, it becomes oxidized itself and inactive, therefore transforming into GSSG