Several questions remain unanswered, including the association between irAEs onset and the type of organ system toxicities, toxicity grading, ITBs, confounding comorbidities like autoimmune diseases, immune heterogeneity and patient intrinsic factors
On the other hand, mounting evidence suggests an association between chronic sleep fragmentation and cyclical episodes of hypoxia-reoxygenation with systemic inflammation, oxidative stress, sympathetic activation, hypothalamic-pituitary axis stimulation, adipokine dysregulation, and increased risk for weight gain
(PubMed) Ho SC, Su MS
Implementing sustainable methodologies in almost all areas of chemistry, including nanomaterial synthesis 1 entails eliminating toxic reagents and solvents
The CHALLENGE study randomized 889 patients with resected colon cancer (stage III or high-risk stage II) who had completed adjuvant chemotherapy to a structured exercise program with required visits over 3 years (exercise group) or general health-education materials (control group)
It is a story of emerging science, where mechanisms discovered in metabolic research are revealing unexpected connections to neurology