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It can become itchy, swollen, sore, or slightly painful, but usually just goes away on its own

The doctor cites studies showing that oral B12 supplements can maintain adequate levels just as effectively as injections, especially if taken in high doses

Before you consider taking a B12 injection, make sure you inform your doctor as well as your home healthcare service provider: If you have kidney issues or Lebers disease

Clinics often use a smaller needle, apply firm pressure for longer, or pick a different site

In less deficient areas, repeat dose every 5-6 months or as found necessary

It can also be given slowly intravenously or subcutaneously (injected into a vein or under the skin)