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A recent Regeneron COURAGE trial found that people on semaglutide alone lost approximately 34.5% of their total weight as lean mass, a number that gets more concerning the longer you look at it without context

Nyberg J, Anderson MF, Meister B et al (2005) Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation

2015 Jun 4;16(2):1117

Each subscription period following the trial was 12 weeks or three months, so this study followed members for about a year, showing the long-term linkage between digital program engagement and medication program persistence

There are clear signals that something needs to change

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