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Abstract 44: Tissue-Protective Effects of an Erythropoietin Derivative in in vitro and in vivo Models of Skeletal Muscle Ischemia

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The reduction in total drug delivered to the systemic circulation is referred to as the First Pass Effect - reflecting the loss of drug via its first pass thru the GI tissues & liver before it reaches the systemic circulation

They elucidated the functional characteristics of ferroptosis in glaucoma and emphasized how ph-IOP can disrupt iron homeostasis, leading to significant accumulation of free iron in the retina post-injury [324]

The systemic effects of headaches and daytime sleepiness only occurred in 2%