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Key distinctions in the evidence: Tesamorelin: licensed in the US, narrowly indicated, established in HIV-related lipodystrophy, with effects that reverse on stopping treatment Retatrutide: investigational, broader metabolic potential, not yet approved anywhere globally Patients and clinicians should interpret early-phase data for retatrutide with appropriate caution

"I'm always really leery about supplements because they aren't regulated in the same way medications are," she says

Ralph DeFronzo is used without his permission

Speak to your health care provider before stopping GLP1-RAs to discuss when to stop and how to manage your condition

Semaglutide is a GLP-1 medication that helps patients lose 1015% of total body weight