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When a synthetic GLP-1 agonist like semaglutide or tirzepatide activates these receptors, the effects ripple through multiple systems simultaneously

To do this, payers need to assess the long-term ROI of GLP-1s, including the benefits of reduced spend on high-cost comorbidities

Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH

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Loss of appetite: This is part of what helps you lose weight on the medications, but can also lead to too much of a lack of hunger