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The jump from 1mg to 1.7mg (a 70% increase) typically produces more side effects than the jump from 0.25mg to 0.5mg (a 100% increase but from a much lower base)

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The pathogenesis of DN is multifaceted, involving hyperglycemia, dyslipidemia, oxidative stress, mitochondrial dysfunction, and inflammation, which collectively damage peripheral nerves

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Nobruising is purely a mechanical result of needle trauma and has no correlation with medication efficacy

Avoiding sudden movements can also reduce episodes of dizziness