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Diabetes Care 40(10):e139e140
Understanding the potential indirect mechanismsincluding rapid weight loss, electrolyte disturbances, and dehydrationcan help patients and clinicians manage these symptoms effectively
Classically, three metabolic alterations have been identified that contribute to the development of T2DM: 1) insulin resistance, 2) an eventual decrease in insulin secretion from pancreatic beta cells, and 3) an excess production of glucose from the liver
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GLP-1 receptors are widely distributed throughout the central nervous system, including brain regions involved in reward processing, motivation, and addictive behaviorsparticularly the mesolimbic dopamine system, which includes the ventral tegmental area and nucleus accumbens
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