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The answer is probably both direct and indirect, Habegger said

The primary and secondary outcome endpoints of MACE and nonfatal stroke demonstrated significant reductions in the dulaglutide-treated REWIND trial and the subcutaneous semaglutide-treated SUSTAIN-6 study [41]

Not dramatically overweight by any measure, but nowhere near where I wanted to be

This is a mechanism no approved drug currently uses Phase 2 trials showed up to 24% body weight reduction over 48 weeks, meaningfully exceeding tirzepatide and semaglutide outcomes Phase 3 trials are currently underway

Injectable options like Wegovy are available via specialist NHS weight management clinics, though waiting lists can be long

A separate analysis of the STEP 1 data found that lean mass was reduced by 6.92 kg with a total weight reduction of 15.3 kg, meaning roughly 45 percent of the weight lost was lean mass