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A randomized, double-blind, placebo-controlled clinical trial with 225 overweight and obese adults found that B420 supplementation over six months was associated with statistically significant changes in body fat mass and waist circumference compared to placebo

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Simultaneously, the significantly diminished proportion of Fe 3+ /Fe 2+ ratio further indicated that UPFB was utilized to exhaust GSH through a redox reaction (Figure 7F)