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For once-weekly preparations such as semaglutide and dulaglutide, the time of day is generally flexible and based on personal preference , as these long-acting formulations maintain steady therapeutic levels throughout the week

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Combinations of GLP-1 with other entero-pancreatic hormones with complementary actions and/or synergistic potential (such as glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin) are under investigation to enhance the weight loss and cardiometabolic benefits of GLP-1 RA [21]

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