glp 1 for liver Multiple target tissue effects of GLP-1 analogues on non-alcoholic fatty disease (NAFLD) and non-alcoholic steatohepatitis (NASH) Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic

Zeng Q, Xu J, Mu X, Shi Y, Fan H, Li S

Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]

However, the Cleveland Clinic Journal of Medicine 30 positions that the benefits of GLP-1 medications outweigh the risks and until more is known, there's little reason to withhold use unless coming from a personal or family history of medullary or follicular thyroid cancers

In addition, GLP-1 is protective against neuronal cell death [17, 18]

Colas, C

targeted the IP3 receptor (IP3R) channels and induced the downstream pro-apoptotic Ca 2+ -signaling pathway via synthesizing a peptide named Bcl-2 IP3 receptor disrupter-2 (BIRD-2) mimicking the structure of the BH4 domain of Bcl-2