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While the mechanism is plausible, the evidence does not yet exist to say what it does in people, at what dose, for what problem, or in which populations, especially in women
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The consistent elevation of BCAA catabolites, particularly 2-oxoisocaproic acid (Ketoleucine) and 3-methyl-2-oxovaleric acid (KMV), suggests an increased reliance on amino acid metabolism to support energy production
At low concentrations in physiological conditions, NO production and inactivation are balanced [140]
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