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It is listed as a rare adverse reaction in UK product information for both oral and injectable B12 preparations, and most people tolerate B12 supplements well even at high doses

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This homeostatic mechanism has been a key focus in wound healing and dermatological research models

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Impaired individuals exhibit hypomethylation of CpG sites in the CCL11 promoter region, which are then hypermethylated upon supplementation with B12 In impaired individuals, three CpG sites exhibited hypomethylation when compared to the non-impaired group