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Consequently, pyridoxine significantly influences the adrenergic, serotonergic, and glutamatergic systems ( Pyridoxine may also exert a protective effect on the nervous system by regulating the glutamatergic system and thus modulating GABA and glutamate levels (60)

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As first described back in the 1950s, about one in ten people erupted in acne within days or even hours of getting an injection of vitamin B12, but it disappeared rapidly when the B12 shots stopped

Watts 2002)

Herein, these four key mechanisms are systematically examined with respect to their molecular regulatory pathways, cellular biological characteristics, and clinical associations, with the aim of providing a comprehensive reference for mechanistic research and therapeutic target development in IBD (Fig

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