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Others experience it as a loss of pleasure or mild emotional flatness around food. Trial mood scores moved slightly better rather than worse, so the negative experience appears to be a minority signal that standard adverse-event tables do not capture well

Some prescription IBD medications, such as sulfasalazine and methotrexate, may interfere with the absorption of folic acid

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Personal Opinion: Based on user reports, I estimate that poor source quality accounts for the majority of complete treatment failures