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Studies in mice, rats, rabbits, and dogs found no severe toxic effects across a wide dose range from 6mcg/kg to 20mg/kg

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As a result, semaglutide was approved for weight loss under the brand name Wegovy

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Garcia-Fernandez M, Sierra I, Puche JE, Guerra L, Castilla-Cortazar I

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Freezing causes the peptide proteins to unfold and clump together, which destroys the medications structure and makes it ineffective

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Circulation 127 , 7485 (2013)

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