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The SURMOUNT-1 DXA substudy (Look et al., 2025) showed that tirzepatide reduced lean body mass by 10.9% over 72 weeks, compared to 2.6% with placebo

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3.2.2 Neurodegenerative disorder Gut microbiota dysbiosis cause high permeability of the intestine and BBB through the gut-brain axis by increasing LPS, T helper cells, pro inflammatory cytokines

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Recuerde que tirzepatide tiene una advertencia en recuadro sobre el riesgo de carcinoma medular de tiroides en pacientes con antecedentes personales o familiares de neoplasia endocrina mltiple tipo 2 (MEN2)