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Abstract Glutathione (GSH) is an endogenous tripeptide (Glu-Cys-Gly) and the most abundant endogenous antioxidant

Thus, glutathione is an essential part of the way cells balance ROS on a constant basis, as well as being available in situations where oxidative stress is generated by toxins, disease, or other pathological conditions.[ref] Glutathione peroxidase (GPX1, GPX2,3,4) antioxidant in cells Glutathione S-transferases (GSTs) are a family of enzymes that bind glutathione to toxic substances to remove them from the cell and then out of the body

The result is often a loop

IshiiTItohKRuizELeakeDSUnokiHYamamotoMet alRole of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages