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This also highlights the need for consideration of haem source in in vitro models, where free haem is typically added as the sole source in culture media: a condition which may not reflect predominant sources in the respiratory and middle ear niches

The medication's enhanced binding affinity to GIP receptors generates additional local inflammatory mediators, including prostaglandins and cytokines, that amplify nociceptor activation

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Most of the data they did find came from studies in animals, including rats, and not humans