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Several factors have contributed to this challenge, including: Increased intake of energy-dense foods high in sugars and fat

Elbadawy NN, Saad MA, Elfarrash S, Ahmed MAE, Abdelkader NF (2025) The GLP-1 agonist semaglutide ameliorates cognitive regression in P301S tauopathy mice model via autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia Polarization

Food and Drug Administration (FDA) indications to match

doi: Center (2023)

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Genetic redundancy within the pathway Given the genetic complexity of the pathway (Table 1), gene-specific Arabidopsis mutants have been very useful in defining the importance of the different isoforms