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Conversely, alternatively activated M2 microglia secrete anti-inflammatory factors, such as IL-10 and TGF-, along with neurotrophic factors, promoting tissue repair and nerve regeneration

This creates a vicious cycle: high histamine levels provoke inflammation, which in turn impairs the bodys ability to metabolize and clear histamines, leading to even more inflammation

Other laboratory discussions suggest aliquoting into smaller portions may reduce repeated freeze-thaw damage if freezing is necessary

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