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Sellings LH, Clarke PB

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This is the most commonly used approach, and its strategy is to modify the second N-terminal amino acid position (Ala8) to protect from degradation by DPP-4

Gradient of risk and associations with cardiovascular efficacy of ertugliflozin by measures of kidney function: observations from VERTIS CV

Some people develop significant constipation with hard, difficult-to-pass stools, going 5+ days without bowel movements, severe bloating and abdominal discomfort, and requiring multiple interventions for relief

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