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The evidence reviewed herein does not yet support formal treatment guidelines, given the predominance of low-level data and the absence of head-to-head trials in MC4R -deficient populations

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Disease states, including iron-deficiency anemia (Ramachandran and Iyer, 1974), severe uremia, cirrhosis of the liver, and hypothyroidism lead to increased erythrocyte glutathione reductase activity

RAI can also be introduced by moving straight to a basal-bolus regimen