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You can increase the dose as far as about 1mg but any higher is generally not advised and the users dosing 1mg/dose normally weigh around the 100kg mark

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But I can tell you that the women I work with consistently tell me they wish theyd found this approach sooner

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Wine drinkers in observational data often show slightly better health outcomes than beer or spirits drinkers but this is almost certainly confounded by lifestyle factors (wine drinkers tend to have higher incomes, better diets, etc.) rather than a specific wine ingredient