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Current methods in imaging the BBB The pathophysiological changes that occur at the BBB in neuroinflammation and AD can be identified in vivo by imaging extravasation of specific solutes into the CNS (Sweeney et al., 2018, 2019

As you perform microneedling, the microchannels created in the skin will drive the peptide deeper into the dermis, where it can activate repair mechanisms at a cellular level

Indeed, in a retrospective study, administration of anti-tumor necrosis factor (anti-TNF) to clinically diagnosed IBD patients led to a 78% reduction in the risk of developing PD, compared to untreated controls (Peter et al., 2018)

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