Kocak, H
& Sela, M
Cell experiments further confirmed that metformin treatment significantly enhanced the expression and phosphorylation of AMPK and ULK1 in mouse hippocampal neuronal cell injury models treated with HG and OGD/R, thereby activating PINK1/Parkin mediated mitophagy
While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)
This often includes eliminating processed foods, sugar, gluten, and dairy while emphasizing whole foods, fiber-rich vegetables, healthy fats, bone broth, and fermented foods that help restore the microbiome
Autonomic Neurosci