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This can lead to all kinds of oxidative damage to cells and their death, and thus, pathological symptoms and comorbidities

Circulation 137 , 455463 (2018)

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression