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Passive targeted delivery involves the use of carrier systems that prolong residence time and increase bioavailability, leading to higher therapeutic efficacy

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253 GLP-1 secretion from L-cells increases substantially in response to many cytokines such as interleukin-6, and interestingly, GLP-1 levels are elevated in patients with sepsis and are correlated with the severity of illness and clinical outcomes, although it is currently unclear if the elevation of GLP-1 levels exacerbates or alleviates pathology during sepsis

10.3389/fimmu.2019.02067 445 UhdeM.IndartA

Data are representative of four independent experiments and the K d values are calculated as the arithmetic mean and s.e.m