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In other words, a high test result may reflect recent intake rather than a medical problem

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Oxidative stress (formulated in Harman's free radical theory of aging) is also thought to contribute to the process

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Specifically, we detected higher expression of the ferritinophagy mediator NCOA4 (encoding nuclear receptor coactivator 4, which binds to ferritin and delivers it to the autophagy-lysosomal machinery) 63 , as well as MCOLN1 (encoding mucolipin transient receptor potential cation channel, also known as TRPML1), which transports iron from the lysosomes to the cytoplasm 67 and is required for lysosomal biogenesis 68 (Fig

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