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In April 2007, the US Food & Drug Administration (FDA) approved the administration of pimobendan only for MVD-affected dogs in heart failure (Stage C), and then in June 2022, the FDA conditionally approved pimobendan to treat MVD-dogs with significantly enlarged left heart chambers (Stage B2)

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Oxidative stress was evaluated through total antioxidant capacity (TAC) and malondialdehyde (MDA) biomarkers in blood samples