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Since its discovery in 1973, almost four decades of extensive research have established its diverse beneficial actions in many organs and tissues including nervous tissue, skin, intestine, bone, and blood vessels

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The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once

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