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Taken together, these studies suggest that the endocrine action of IGF-1 plays a lesser role in skeletal growth, and is mostly confined to periosteal growth

Citation on PubMed or Free article on PubMed Central Schimmenti LA, Crombez EA, Schwahn BC, Heese BA, Wood TC, Schroer RJ, Bentler K, Cederbaum S, Sarafoglou K, McCann M, Rinaldo P, Matern D, di San Filippo CA, Pasquali M, Berry SA, Longo N

In all three cell lines lysosome-associated membrane protein 2 ( LAMP2 ), which maintains lysosomal integrity and function, was downregulated by IGF-1

Evidence gap There is no modern, large-sample, FDA-recognized RCT establishing DSIP's efficacy in any indication

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