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doi: 10.1161/CIRCRESAHA.116.305360

Retatrutide produced 24.2% mean body-weight reduction at 48 weeks in phase 2

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Side effects may feel stronger if you: Naturally have a sensitive stomach Eat large, high-fat, or heavy meals Increase your dose too quickly Skip meals or go long periods without eating Lose weight rapidly Have underlying digestive conditions (IBS, GERD, etc.) Working with a provider who customizes your dosing makes a meaningful difference in comfort levels

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Mike Wilson: Yeah, we would agree with that