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The localized and time-limited nature of angiogenic activity in wound healing models differs mechanistically from the sustained, dysregulated vascular recruitment characteristic of tumor growth

This is the safest point to begin to assess tolerance and minimize the risk of side effects

With that in mind its expected to submit the drug for regulatory approval towards the end of 2025, meaning it may be available as soon as 2026

While nausea and diarrhea are often more frequently discussed, constipation is also a recognized side effect

Conflicts of Interest The authors declare no conflicts of interest in this study

This becomes even more relevant when combining AOD-9604 with training