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Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) studies have shown widespread reductions in cerebral metabolism, while functional Magnetic Resonance Imaging (fMRI) studies have revealed more pronounced alterations in functional brain networks in TLE patients with depression (Struck et al., 2021)

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This may be due to the AS-IV-induced upregulation of the expression of ALDH2, which inhibits autophagy by regulating the AKT/mTOR pathway (Yadan et al., 2024

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Metabolic Health and Hormonal Balance GH secretagogue protocols are typically embedded within broader hormone optimization frameworks that address thyroid function, sex hormone levels, insulin sensitivity, and adrenal health