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Description

Okatani et al., 2002

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PARP-1 contributes significantly by selectively binding to cisplatin-induced DNA damage, particularly 1, 2-d(GpG) crosslinks ( Table 4 )

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These animal results generated significant excitement and justified moving to human trials

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Brown KM, Pickard K, Nicol F, Beckett GJ, Duthie GG, Arthur JR

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FDA approval is expected in 2026

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Heerspink HJL, Stefansson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, et al

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